Key result
Upper body obese women stored a significantly greater proportion of free fatty acids in upper body subcutaneous fat compared with lean women (P<0.01).
Why the study?
Does body fat distribution determine direct FFA storage patterns in overweight women?
Observational (n=28)
Does body fat distribution determine direct FFA storage patterns in overweight women?
Body fat distribution determines direct free fatty acid storage patterns, with upper body obese women storing more in upper body subcutaneous fat and lower body obese women storing more efficiently in lower body subcutaneous fat.
Answers are grounded in this paper and cite their sources.
Upper body obesity may alter FFA storage patterns; cross-sectional data leaves open causal role of fat distribution.
Direct FFA storage in adipose tissue is a recently appreciated pathway for postabsorptive lipid storage. We evaluated the effect of body fat distribution on direct FFA storage in women with different obesity phenotypes. Twenty-eight women [10 upper body overweight/obese (UBO; WHR >0.85, BMI >28 kg/m(2)), 11 lower body overweight/obese (LBO; WHR <0.80, BMI >28 kg/m(2)), and 7 lean (BMI <25 kg/m(2))] received an intravenous bolus dose of [9,10-(3)H]palmitate- and [1-(14)C]triolein-labeled VLDL tracer followed by upper body subcutaneous (UBSQ) and lower body subcutaneous (LBSQ) fat biopsies. Regional fat mass was assessed by combining DEXA and CT scanning. We report greater fractional storage of FFA in UBSQ fat in UBO women compared with lean women (P < 0.01). The LBO women had greater storage per 10(6) fat cells in LBSQ adipocytes compared with UBSQ adipocytes (P = 0.04), whereas the other groups had comparable storage in UBSQ and LBSQ adipocytes. Fractional FFA storage was significantly associated with fractional VLDL-TG storage in both UBSQ (P < 0.01) and LBSQ (P = 0.03) adipose tissue. In conclusion, UBO women store a greater proportion of FFA in the UBSQ depot compared with lean women. In addition, LBO women store FFA more efficiently in LBSQ fat cells compared with UBSQ fat cells, which may play a role in development of their LBO phenotype. Finally, direct FFA storage and VLDL-TG fatty acid storage are correlated, indicating they may share a common rate-limiting pathway for fatty acid storage in adipose tissue.
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Søndergaard et al. (2012) conducted an observational in Obesity (n=28). Upper body overweight/obese phenotype vs. Lean phenotype was evaluated on Fractional storage of FFA in upper body subcutaneous (UBSQ) fat (p=<0.01). Upper body obese women stored a significantly greater proportion of free fatty acids in upper body subcutaneous fat compared with lean women (P<0.01).
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