Key result
Upper body obese women had significantly greater hepatic VLDL-TG production compared to lower body obese and lean women (64.8 vs 42.5 vs 31.8 mumol/min, P=0.04).
Why the study?
Does body composition affect VLDL-TG kinetics in women?
Population
30 women (10 upper body obese [UBO], 10 lower body obese [LBO], and 10 lean)
Comparison
Upper body obesity and lower body obesity vs Lean body composition
Design
Cross-sectional
Authors
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May link upper-body obesity to hypertriglyceridemia via higher VLDL-TG production in women; hypothesis-generating and requires prospective validation.
Observational (n=30)
Does body composition affect VLDL-TG kinetics in women?
Absolute Event Rate: 64.8% vs 31.8%
p-value: p=0.04
Elevated VLDL-TG production without concomitant increased clearance contributes to hypertriglyceridemia in upper body obese women, potentially explaining their higher cardiovascular risk.
Gormsen et al. (2008) conducted an observational in Obesity (n=30). Upper body obesity vs. Lower body obesity and lean body composition was evaluated on Hepatic VLDL-TG production (mumol/min) (p=0.04). Upper body obese women had significantly greater hepatic VLDL-TG production compared to lower body obese and lean women (64.8 vs 42.5 vs 31.8 mumol/min, P=0.04).
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