April 1, 2003AJP Endocrinology and Metabolism
VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity
Why the study?
Does glucose infusion-induced hyperglycemia-hyperinsulinemia affect VLDL-TG kinetics differently based on sex and obesity?
Population
24 lean and obese men and women (n=6 in each group)
Comparison
Glucose infusion (5.5 mg x kg FFM x min) to… vs Basal, postabsorptive conditions
Design
Other
Authors
Discussion
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Member takes
Implication
Obesity may blunt glucose-mediated VLDL-TG suppression selectively in women; leaves open sex-specific lipid kinetics in metabolic disease.
Structured PICO
Does glucose infusion-induced hyperglycemia-hyperinsulinemia affect VLDL-TG kinetics differently based on sex and obesity?
P
Population
24 lean and obese men and women (n=6 in each group)
I
Intervention
Glucose infusion (5.5 mg x kg FFM(-1) x min(-1)) to induce hyperglycemia-hyperinsulinemia
C
Comparator
Basal, postabsorptive conditions
O
Outcome
VLDL-TG secretion ratesurrogate
Obesity is associated with resistance to glucose- and insulin-mediated suppression of VLDL-TG secretion in women, but not in men.
Cite This Study
Mittendorfer et al. (2003) studied this question.