Key result
Upper-body obesity does not alter visceral fat VLDL-triglyceride storage compared to lean controls.
Why the study?
Does upper-body obesity alter VLDL-triglyceride fractional storage in visceral fat compared to lean women?
Cross-Sectional (n=15)
Does upper-body obesity alter VLDL-triglyceride fractional storage in visceral fat compared to lean women?
Postabsorptive VLDL-TG storage into regional fat depots is similar between upper-body obese and lean women, suggesting this mechanism does not drive the development of preferential upper-body fat accumulation.
Answers are grounded in this paper and cite their sources.
Does not implicate VLDL-TG storage in upper-body fat accumulation; leaves open alternative mechanisms for regional adiposity.
OBJECTIVE: Excess visceral fat accumulation is associated with the metabolic disturbances of obesity. Differential lipid redistribution through lipoproteins may affect body fat distribution. This is the first study to investigate VLDL-triglyceride (VLDL-TG) storage in visceral fat. RESEARCH DESIGN AND METHODS: Nine upper-body obese (UBO; waist circumference >88 cm) and six lean (waist circumference <80 cm) women scheduled for elective tubal ligation surgery were studied. VLDL-TG storage in visceral, upper-body subcutaneous (UBSQ), and lower-body subcutaneous (LBSQ) fat were measured with [9,10-(3)H]-triolein-labeled VLDL. RESULTS: VLDL-TG storage in visceral fat accounted for only ~0.8% of VLDL-TG turnover in UBO and lean women, respectively. A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat. The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots. VLDL-TG fractional storage and VLDL-TG concentration were correlated in UBO women in UBSQ fat (r = 0.68, P = 0.04), whereas an inverse association was observed for lean women in visceral (r = -0.89, P = 0.02) and LBSQ (r = -0.87, P = 0.02) fat. CONCLUSIONS: VLDL-TG storage efficiency is similar in all regional fat depots, and trafficking of VLDL-TG into different adipose tissue depots is similar in UBO and lean women. Postabsorptive VLDL-TG storage is unlikely to be of major importance in the development of preferential upper-body fat distribution in obese women.
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Søndergaard et al. (2011) conducted a cross-sectional in Upper-body obesity (n=15). Upper-body obesity vs. Lean women was evaluated on VLDL-TG fractional storage in visceral fat (p=not significant). Upper-body obesity did not significantly alter VLDL-triglyceride fractional storage in visceral fat compared to lean women (0.76% vs 0.81%), suggesting storage efficiency is independent of adiposity.
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