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April 1, 1989HeartOpen Access

Effect of flosequinan on exercise capacity and symptoms in severe heart failure.

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Why the study?

Does flosequinan improve exercise capacity and symptoms in patients with severe chronic cardiac failure caused by ischaemic heart disease?

Population

20 patients with severe chronic cardiac failure caused by ischaemic heart disease

Comparison

Flosequinan 100 mg daily added to existing… vs Placebo added to existing treatment with…

Design

RCT, randomised, double blind

Follow-up

8 weeks

Authors

JEJ.S. ElbornCSC. F. StanfordDNDP Nicholls

Discussion

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Overview

Flosequinan 100 mg daily improves exercise capacity and symptoms in patients with severe chronic heart failure over 8 weeks.

Structured PICO

Does flosequinan improve exercise capacity and symptoms in patients with severe chronic cardiac failure caused by ischaemic heart disease?

P
Population
20 patients with severe chronic cardiac failure caused by ischaemic heart disease
I
Intervention
Flosequinan 100 mg daily added to existing treatment with diuretics and, in some, digoxin
C
Comparator
Placebo added to existing treatment with diuretics and, in some, digoxin
O
Outcome
Treadmill exercise time, peak achieved oxygen consumption, and New York Heart Association symptom grade at 8 weekssurrogate

Flosequinan 100 mg daily improves exercise capacity and symptoms in patients with severe chronic heart failure over 8 weeks.

Cite This Study

Elborn et al. (1989) studied this question.

synapsesocial.com/papers/6a705bd3e5469ee92be11934https://doi.org/10.1136/hrt.61.4.331
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