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December 1, 1993British Journal of Clinical Pharmacology0 citationsOpen Access

Acute and chronic effects of flosequinan on resting and exercise haemodynamics in congestive heart failure

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Why the study?

Does flosequinan improve resting and exercise haemodynamics in male patients with congestive heart failure?

Population

12 male patients with congestive heart failure (NYHA class II and III), mean age 58.9 years.

Comparison

Flosequinan 125 mg orally vs Baseline and sublingual glyceryl trinitrate for…

Design

Case_series

Follow-up

8 weeks

Authors

PTPatrick B. ThomasDOD. J. O'GormanDSDesmond J. Sheridan

Discussion

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Overview

Flosequinan provides sustained improvements in resting and exercise haemodynamics in patients with congestive heart failure over 8 weeks of therapy.

Structured PICO

Does flosequinan improve resting and exercise haemodynamics in male patients with congestive heart failure?

P
Population
12 male patients with congestive heart failure (NYHA class II and III), mean age 58.9 years.
I
Intervention
Flosequinan 125 mg orally (acute single dose and chronic 125 mg daily for 8 weeks)
C
Comparator
Baseline (pre-treatment) and sublingual glyceryl trinitrate (0.5 mg) for acute comparison
O
Outcome
Resting and exercise haemodynamic responses (right atrial pressure, pulmonary artery pressure, pulmonary wedge pressure, systemic pressure, heart rate, systemic vascular resistance, cardiac index)surrogate

Flosequinan provides sustained improvements in resting and exercise haemodynamics in patients with congestive heart failure over 8 weeks of therapy.

Cite This Study

Thomas et al. (1993) studied this question.

synapsesocial.com/papers/6a72a515febe604dd70ab3e6https://doi.org/10.1111/j.1365-2125.1993.tb00412.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemodynamic and neurohormonal effects of flosequinan in patients with heart failure1997 · 5 citations
  2. 2The effects of flosequinan on submaximal exercise in patients with chronic cardiac failure.1990 · 10 citations
  3. 3The Effect of Flosequinan (BTS 49 465) in Patients with Heart Failure. Hemodynamic Effects of a Single Oral Dose.1992 · 1 citations
  4. 4Effect of flosequinan on exercise capacity and symptoms in severe heart failure.1989 · 49 citations
  5. 5Chronic vasodilator therapy with flosequinan in congestive heart failure1990 · 12 citations