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Synapse
January 2, 1997Fundamental and Clinical Pharmacology5 citations

Hemodynamic and neurohormonal effects of flosequinan in patients with heart failure

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Why the study?

Does flosequinan alter hemodynamic and neurohormonal parameters in patients with congestive heart failure?

Population

18 patients with congestive heart failure

Comparison

Flosequinan 100 mg oral, evaluated after first… vs Placebo

Design

RCT, double-blind

Follow-up

10 days

Authors

RIRichard IsnardPLP LechatFPFrançoise Pousset

Discussion

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Overview

Flosequinan provides favorable hemodynamic effects but causes neurohormonal activation, potentially explaining its adverse effects on survival in heart failure.

Structured PICO

Does flosequinan alter hemodynamic and neurohormonal parameters in patients with congestive heart failure?

P
Population
18 patients with congestive heart failure
I
Intervention
Flosequinan 100 mg oral, evaluated after first administration and after 10 days of treatment
C
Comparator
Placebo
O
Outcome
Central and peripheral hemodynamic effects and neurohormonal activationsurrogate

Flosequinan provides favorable hemodynamic effects but causes neurohormonal activation, potentially explaining its adverse effects on survival in heart failure.

Cite This Study

Isnard et al. (1997) studied this question.

synapsesocial.com/papers/6a72a515febe604dd70ab3e5https://doi.org/10.1111/j.1472-8206.1997.tb00173.x
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