Effects of Renal Sympathetic Denervation on Exercise Blood Pressure, Heart Rate, and Capacity in Patients With Resistant Hypertension
Key result
Renal denervation reduced exercise systolic blood pressure at rest from 158 to 141 mm Hg (P<0.001) at 6 months and improved exercise capacity in patients with resistant hypertension.
Why the study?
Does renal denervation reduce exercise blood pressure and heart rate and improve exercise capacity in patients with resistant hypertension?
Population
60 patients with resistant hypertension (n=50 in renal denervation group, n=10 in control group)
Comparison
Renal denervation vs Control group
Design
Cohort
Follow-up
6 and 12 months
Authors
Discussion
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Member takes
Implication
May reduce exercise BP and boost capacity in resistant hypertension; hypothesis-generating, needs RCTs before practice change.
Study Design
Type
Cohort (n=60)
Structured PICO
Does renal denervation reduce exercise blood pressure and heart rate and improve exercise capacity in patients with resistant hypertension?
P
Population
60 patients with resistant hypertension (50 undergoing renal denervation, 10 controls) evaluated at 6 and 12 months.
E
Exposure
Renal denervation
C
Comparator
Control group
O
Outcome
Blood pressure, heart rate, and chronotropic index at rest, during exercise, and at recovery using a standardized bicycle exercise test protocolsurrogate
Main Result
p-value: p=<0.001
Renal denervation significantly reduces resting and exercise blood pressure and heart rate while improving exercise capacity in patients with resistant hypertension.
Cite This Study
Ewen et al. (2014) conducted a cohort in Resistant hypertension (n=60). Renal sympathetic denervation vs. Control group was evaluated on Exercise blood pressure at rest at 6 months (p=<0.001). Renal denervation reduced exercise systolic blood pressure at rest from 158 to 141 mm Hg (P<0.001) at 6 months and improved exercise capacity in patients with resistant hypertension.