Why the study?
Does glucose-insulin-potassium infusion improve left ventricular function during acute regional ischemia in a canine model?
Population
Intact anesthetized dogs with acute regional ischemia induced by a balloon tip catheter in the left anterior…
Comparison
Glucose infusate administered with insulin and… vs Isovolumic saline
Design
Preclinical
Follow-up
4 hours (acute phase), 4 months (long-term subgroup)
Authors
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May support acute LV performance during canine ischemia without limiting scar; leaves open translation of metabolic support to human MI.
Does glucose-insulin-potassium infusion improve left ventricular function during acute regional ischemia in a canine model?
Glucose-insulin-potassium infusion improves acute ventricular performance during myocardial ischemia in a canine model, but appears to delay rather than prevent irreversible necrosis.
Ahmed et al. (1978) studied this question.
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