Key result
Left ventricular motion (time to peak annular systolic velocity) was directly related to carotid time to the inflection point (R2 = 0.81; P < 0.01), questioning AIx as a measure of aortic stiffness.
Why the study?
Does left ventricular systolic function influence central pressure waveform morphology (AIx and Ti) in healthy young men?
Cross-Sectional (n=20)
Does left ventricular systolic function influence central pressure waveform morphology (AIx and Ti) in healthy young men?
Effect estimate: R2 = 0.81
p-value: p=<0.01
In healthy young men, central augmentation index and time to inflection point may be substantially determined by left ventricular systolic function rather than solely arterial stiffness, questioning its standard interpretation.
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May question AIx as stiffness marker in young men; leaves open LV contributions to waveforms pending prospective studies.
Cheng et al. (2012) conducted a cross-sectional in Healthy (n=20). Left ventricular motion was evaluated on Relationship between time to peak annular systolic velocity and carotid time to the inflection point (Ti) (R2 = 0.81, p=<0.01). Left ventricular motion (time to peak annular systolic velocity) was directly related to carotid time to the inflection point (R2 = 0.81; P < 0.01), questioning AIx as a measure of aortic stiffness.
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