Key Points
- To identify prospective clinical, metabolic, and hemodynamic predictors of changes in central augmentation index over time in a population-based adult cohort.
- Assessed 143 nondiabetic adults (67 men, 76 women) enrolled in the population-based PREVENCION study.
- Measured central augmentation index using radial arterial tonometry and the generalized transfer function of the Sphygmocor system across a median follow-up of 3.18 ± 0.4 years.
- In men (n = 67), longitudinal augmentation index increases were predicted by waist circumference (standardized β = 0.34; P = 0.002), impaired fasting glucose (standardized β = 0.24; P = 0.009), and heart rate change (standardized β = -0.78; P < 0.001).
- In women (n = 76), augmentation index increases were predicted by non-HDL cholesterol (standardized β = 0.33; P = 0.001), C-reactive protein (standardized β = 0.24; P = 0.02), mean arterial pressure change (standardized β = 0.33; P = 0.001), and heart rate change (standardized β = -0.52; P < 0.001).
Structured PICO
PPopulation143 nondiabetic adult participants from the general population (PREVENCION study), including 67 men and 76 women
OOutcomePredictors of changes in central augmentation index (AIx) over timesurrogate
Metabolic and inflammatory factors predict longitudinal changes in arterial stiffness, with distinct sex-specific predictors such as abdominal obesity in men and non-HDL cholesterol in women.