Key result
Glucagon infusion increased energy expenditure by 15% (p < 0.05 vs control), similar to cold exposure, but without activating brown adipose tissue thermogenesis.
Why the study?
Does glucagon infusion increase energy expenditure and brown adipose tissue activation compared to cold exposure in healthy male volunteers?
Population
11 healthy male volunteers
Comparison
Glucagon infusion (50 ng/kg/min at 23 °C) vs Cold exposure and vehicle infusion (at 23 °C)
Design
Other, randomly allocated second (18)F-FDG PET/CT scan
Authors
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May support glucagon as BAT-independent thermogenic agent; hypothesis-generating for obesity therapies pending randomized trials.
RCT (n=11)
Randomly allocated
Does glucagon infusion increase energy expenditure and brown adipose tissue activation compared to cold exposure in healthy male volunteers?
p-value: p=< 0.05
Glucagon increases energy expenditure to a similar degree as cold exposure, but does so independently of brown adipose tissue thermogenesis.
Salem et al. (2015) conducted an RCT in Healthy volunteers (n=11). Glucagon infusion vs. Vehicle infusion and cold exposure was evaluated on Energy expenditure (EE) (p=< 0.05). Glucagon infusion increased energy expenditure by 15% (p < 0.05 vs control), similar to cold exposure, but without activating brown adipose tissue thermogenesis.
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