Key result
Combined exercise training reduced mean arterial pressure (158 vs 174 mmHg) and heart rate (303 vs 403 beats/min) in a rat model of metabolic syndrome and menopause.
Why the study?
Does combined exercise training improve cardiovascular, autonomic, inflammatory, and oxidative stress parameters in a rat model of metabolic syndrome and menopause?
Does combined exercise training improve cardiovascular, autonomic, inflammatory, and oxidative stress parameters in a rat model of metabolic syndrome and menopause?
Absolute Event Rate: 158% vs 174%
Combined aerobic and resistance exercise training attenuates cardiovascular, autonomic, inflammatory, and oxidative stress dysfunctions in a rat model of menopause and metabolic syndrome.
Supports combined exercise in a rat metabolic syndrome-menopause model; hypothesis-generating and requires clinical validation.
It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistar rats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 ± 4 vs. C: 108 ± 1 mmHg), heart rate (FHO: 403 ± 12 vs. C: 352 ± 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-α-FHO: 65.8 ± 9.9 vs. C: 23.3 ± 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 ± 4 mmHg), heart rate (FHOT: 303 ± 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-α (FHOT: 33.1 ± 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions.
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Conti et al. (2015) studied Metabolic syndrome and menopause (n=24). Combined exercise training (CT) vs. Sedentary (FHO) was evaluated on Mean arterial pressure (mmHg). Combined exercise training reduced mean arterial pressure (158 vs 174 mmHg) and heart rate (303 vs 403 beats/min) in a rat model of metabolic syndrome and menopause.
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