Why the study?
Does prostacyclin prevent cognitive deficits in open heart surgery patients?
Does prostacyclin prevent cognitive deficits in open heart surgery patients?
Prostacyclin does not appear to prevent cognitive deficits following open heart surgery and may be associated with visual retention deficits.
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Prostacyclin should not be used to prevent cognitive deficits after open heart surgery; hypothesis-generating for domain-specific effects.
Two groups of open heart surgery patients, one receiving prostacyclin and one placebo, were assessed one week pre-operatively and 3 months post-operatively, using a battery of clinical tests measuring a variety of cognitive functions. No significant differences between the groups were detected, apart from a visual retention deficit at 3 months in the prostacyclin group. The results cast doubt on previous findings suggesting that prostacyclin reduces cognitive deficits following open heart surgery.
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Pears et al. (1984) studied this question.
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