Key result
Compared to patients aged 65-80 years, those >80 years had a significantly higher prevalence of at least one target organ damage (OR 2.07; 95% CI 1.52-2.80; p=0.00001).
Cross-Sectional (n=725)
Odds Ratio: 2.07 (95% CI 1.52–2.8)
p-value: p=0.00001
Very elderly patients (>80 years) exhibit a significantly higher burden of target organ damage, chronic kidney disease, and cardiovascular disease compared to those aged 65-80 years, highlighting the need for targeted management in this high-risk population.
Associated with higher target organ damage in hypertensives >80 years; hypothesis-generating for age-specific strategies, requiring prospective validation.
Objectives: The prevalence of hypertension (HT) in >65 years is high, however people >80 years represent one of the most forgotten, despite the high prevalence of HT. Our objective was to determine the clinical characteristics of the population >80 years who attended our consultation. Methods: Cross-sectional study, during 2009, which included patients >65 years. We studied: demographic parameters, cardiovascular risk factors (CRF), target organ damage (TOD) and comorbidity. Statistical analyses of qualitative variables are in percentages and frequencies, numerical in standard deviation; comparison of categorical variables using X2 test and for continuous T-student test. A p value <0.05 was considered significant. Results: There was 307 patients >80 years and 418 between 65–80 years. In patients >80 years, 61.2% were men, 84.7% had hypertension, 57% CKD (GFR <60 ml/min/1,73m2), 28% cardiopathy, 13% stroke, 49.5% had at least 1 TOD, 67% had 3 or more CRF, and Charlson index was 8.97 ± 2.07. Comparing these patients with 65–80 years, we find no differences for sex, HT, smoking, diabetes and peripheral vascular disease. Patients >80 years had less obesity (p:0.0004; OR:0.57 CI95%: 0.41–0.78), dyslipidemia (p:0.00002, OR:0.53 CI95%: 0.39–0.71), however had a high prevalence of cardiopathy (cardiac insufficiency, myocardial infarction, LVH) (p:0.0002, OR:1.9 CI95%: 1.35–2.76), stroke (p:0.008, OR:1.93 CI95%: 1.17–3.18), CKD (p:0.00001, OR:2.33 CI95%: 1.72–3.15), presence at least 1 TOD (p:0.00001, OR:2.07, CI95%: 1.52–2.80). The BMI is lower (p:0.0003), but had a high number of TOD, CRF and Charlson I. (p:0.00001). Conclusions: HT is very prevalent in our population. Compared to the classic group of > 65 years they have a great number of CRF and TOD. While the magnitude of risk tends to be lower after 65 years, the absolute risk is greater because the CRF are more prevalent and frequently associated with increasing age, which has a multiplier effect. Studies are needed to selectively target this age group while existing information is variable and inconsistent.
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Chevarría et al. (2010) conducted a cross-sectional in Hypertension and cardiovascular risk (n=725). Age >80 years vs. Age 65-80 years was evaluated on Presence of at least 1 target organ damage (TOD) (OR 2.07, 95% CI 1.52-2.80, p=0.00001). Compared to patients aged 65-80 years, those >80 years had a significantly higher prevalence of at least one target organ damage (OR 2.07; 95% CI 1.52-2.80; p=0.00001).
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