Key result
Patients with cardiac insufficiency had a significantly higher VE/VCO2 slope (38.8 vs 28.2 L/min, p<0.003) and lower OUES (1.81 vs 2.3, p<0.05) during exercise compared to healthy controls.
Why the study?
Heart failure results in cardiorespiratory impairment during physical effort, prompting a comparison of cardiorespiratory variables, oxygen uptake efficiency slope, and the VE/VCO2 relationship between individuals with heart failure and healthy individuals.
Do patients with cardiac insufficiency have altered VE/VCO2 and OUES during progressive exercise compared to healthy individuals?
Observational (n=61)
Do patients with cardiac insufficiency have altered VE/VCO2 and OUES during progressive exercise compared to healthy individuals?
Absolute Event Rate: 38.8% vs 28.2%
p-value: p=<0.003
Patients with heart failure exhibit significant cardiorespiratory impairment during exercise, characterized by elevated VE/VCO2 slope and reduced OUES, indicating early metabolic acidosis and limited functional capacity.
May aid noninvasive assessment of cardiac insufficiency; extends observational CPET data but leaves clinical adoption open.
Introduction: Heart failure originates from several etiologies resulting in cardiorespiratory impairment during physical effort. Objective: To compare the behavior of cardiorespiratory variables, slope of oxygen uptake efficiency slope and the relationship between pulmonary ventilation and carbon dioxide production between individuals with heart failure and healthy individuals. Methods: 61 male individuals (61.2 ± 7.8 years) were evaluated, who were separated into two groups: Group CI - Patients with Cardiac Insufficiency (n = 40) and Group C - Control (n = 21). The volunteers performed assessments of the following parameters: age, height, body mass and body mass index. The ergospirometry test was also performed, consisting of performing a graded exercise testing on a treadmill with direct analysis of the respiratory gases: VE/VCO2, VO2peak, PetCO2, OUES and the hemodynamic variables: maximum heart rate, recovery heart rate after the 1st minute and the echocardiogram. The Kolmorovsminoff test for normality was performed, the data were expressed as mean and standard error and the inferential analysis performed with the Anova and Post-Hoc Tests of Scheffé, considering p≤0.05. Results: The anthropometric, hemodynamic and respiratory variables results for the CI and C groups, respectively, were: age =61,0±8,2 vs. 61,5±7,4 years (p>0,05), height= 1,72±5,8 vs. 1,72±6,8m (p>0,05), body mass = 77,3±9,9 vs. 78,3±9,0kg (p>0,05), IMC = 26,5±3,0 vs. 26,2±2,8 kg/m2 (p>0,05), ejection fraction = 31,2±4,1 vs. 64,7±3,9mL (p<0,001), maximum cardio frequency = 128,6±22,9 vs. 143,6±15,5bpm (p<0,02), recovery heart rate after the 1st minute = -17,4±5,4 vs. -25,0±4,9bpm (p<0,05), VE/VCO2slope = 38,8±5,6 vs. 28,2±3,9L/min (p<0,003), VO2peak = 20,0±4,0 vs. 36,7±5,5ml/kg/min (p<0,05), PetCO2 = 29,5±3,0 vs. 31,7±2,4mmHg (p<0,05) and OUES = 1,81±0,4 vs. 2,3±0,3 (p<0,05). Conclusion: Patients with heart failure showed high values of VE/VCO2 and low values of OUES, which limits functional capacity and leads to the early onset of metabolic acidosis. Level of Evidence I; High-Quality Prospective Study.
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Aguillar et al. (2023) conducted an observational in Cardiac Insufficiency (n=61). Cardiac Insufficiency vs. Healthy controls was evaluated on VE/VCO2 slope (p=<0.003). Patients with cardiac insufficiency had a significantly higher VE/VCO2 slope (38.8 vs 28.2 L/min, p<0.003) and lower OUES (1.81 vs 2.3, p<0.05) during exercise compared to healthy controls.
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