Key result
In patients with COPD, changes in cardiointervalogram parameters during external peripheral vascular occlusion were less pronounced than in healthy volunteers, indicating hyperactivation of the ergoreflex.
Why the study?
To evaluate changes in the cardiointervalogram during external peripheral vascular occlusion testing in patients with COPD versus individuals without respiratory system diseases.
Does the test with external peripheral vascular occlusion reveal differences in ergoreflex and autonomic status between patients with COPD and healthy volunteers?
Cross-Sectional (n=105)
No
Does the test with external peripheral vascular occlusion reveal differences in ergoreflex and autonomic status between patients with COPD and healthy volunteers?
p-value: p=>0.05
Patients with COPD exhibit hyperactivation of the ergoreflex and autonomic imbalance characterized by sympathetic predominance compared to healthy individuals.
Ergoreflex hyperactivation may contribute to symptoms in COPD; leaves open its clinical relevance pending prospective studies.
Aim. To evaluate changes in the cardiointervalogram (CIG) in the test with external peripheral vascular occlusion in patients with chronic obstructive pulmonary disease (COPD) and in individuals without diseases of the respiratory system. Materials and Methods. The study included 105 men, of them 64 patients with COPD (age 64.988.67) and 41 volunteers without diseases of the respiratory system (age 61.689.21). The autonomic status was examined and alterations in CIG in the test with occlusion were evaluated on Varicard hardware and software complex (OOO Ramena, Russia). Results. The obtained data showed the autonomic imbalance with predomination of the activity of sympathetic division of the autonomic nervous system (ANS) in patients with COPD as compared to the control group (p0.05). A study of ergoreflex by analysis of changes in CIG showed reduction of the activity of sympathetic division of the ANS in the test with external peripheral vascular occlusion in individuals without diseases of the respiratory system. In patients with COPD, changes in CIG in the test were less expressed and not always achieved statistically significant level (p0.05). Conclusions. Differences in the results of the test with external peripheral vascular occlusion in patients with COPD and volunteers without diseases of the respiratory system are attributed to hyperactivation of ergofeflex in patents with COPD.
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Kosyakov et al. (2020) conducted a cross-sectional in Chronic obstructive pulmonary disease (COPD) (n=105). Chronic obstructive pulmonary disease (COPD) vs. Volunteers without respiratory diseases was evaluated on Changes in cardiointervalogram (CIG) parameters reflecting sympathetic nervous system activity during external peripheral vascular occlusion (p=>0.05). In patients with COPD, changes in cardiointervalogram parameters during external peripheral vascular occlusion were less pronounced than in healthy volunteers, indicating hyperactivation of the ergoreflex.
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