October 1, 1992Hypertension

Collagen deposition and the reversal of coronary reserve in cardiac hypertrophy.

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Why the study?

Does inhibition of collagen deposition with beta-aminopropionitrile improve coronary dilator reserve after relief of pressure overload in rats with cardiac hypertrophy?

Structured PICO

Does inhibition of collagen deposition with beta-aminopropionitrile improve coronary dilator reserve after relief of pressure overload in rats with cardiac hypertrophy?

Population

Rats with pressure-overloaded cardiac hypertrophy induced by ascending aortic banding

Intervention

Beta-aminopropionitrile (50 mg/kg i.p., twice a day) during 10 weeks of banding, followed by debanding for 4 weeks

Comparator

Banding without beta-aminopropionitrile treatment followed by debanding, and unbanded controls

Outcome

Coronary dilator reserve (ratio of reactive peak flow after brief ischemia-to-resting flow) in Langendorff preparationssurrogate

Inhibition of collagen deposition during pressure overload allows for the restoration of coronary vasodilator reserve upon relief of the overload in a rat model.

Discussion

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Implication

Collagen inhibition may restore coronary reserve after pressure overload relief in rats; leaves open translation to human hypertrophy.

Cite This Study

Isoyama et al. (1992) studied this question.

synapsesocial.com/papers/6a7063befebe604dd7092bad https://doi.org/10.1161/01.hyp.20.4.491

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Collagen deposition and the reversal of coronary reserve in cardiac hypertrophy.

Structured PICO

Discussion

Implication

Cite This Study

Topics

Collagen deposition and the reversal of coronary reserve in cardiac hypertrophy.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider