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March 1, 1993Journal of Clinical InvestigationOpen Access

Regulation of procollagen metabolism in the pressure-overloaded rat heart.

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Population

Young rats subjected to abdominal aortic banding to induce sustained hypertension and mild left ventricular…

Design

Preclinical

Follow-up

1-16 weeks

Authors

EEElias G. EleftheriadesBioClinicum (Russia)JDJean‐Bernard DurandCardio-OncologyAFA. G. FergusonUniversity of Nairobi

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Overview

Hypothesis-generating for dual regulation of myocardial fibrosis in hypertension; human validation required before clinical translation.

Structured PICO

P
Population
Young rats subjected to abdominal aortic banding to induce sustained hypertension and mild left ventricular hypertrophy.
I
Intervention
Abdominal aortic banding (pressure overload) evaluated at 1-16 weeks.
O
Outcome
In vivo rate of procollagen synthesis, collagen accumulation, intracellular procollagen degradation, and tissue mRNA levels for type I and type III procollagen polypeptides.surrogate

Fibrillar collagen deposition in the myocardial extracellular matrix during sustained hypertension is regulated by both pretranslational and posttranslational mechanisms.

Cite This Study

Eleftheriades et al. (1993) studied this question.

synapsesocial.com/papers/6a8a796b6fc170cbc2fbf24bhttps://doi.org/10.1172/jci116270

Topics

Hypertension management
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Also Consider

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