Key result
Murine norovirus strains MNV-1 and CR3 evolved multiple strategies to bind different glycan receptors on murine macrophages, contributing to differences in tissue tropism in vivo.
Population
Murine norovirus strains MNV-1 and CR3, murine macrophages, and in vivo murine models
Comparison
Analysis of glycan-binding specificities… vs Comparison between MNV-1 and CR3 strains, and…
Design
Preclinical
Authors
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Animal data on norovirus receptor strategies warrant no clinical changes; leaves open human translation and therapeutic targeting.
Murine norovirus strains utilize distinct glycan-binding strategies that influence their tissue tropism in vivo.
Taube et al. (2012) studied Norovirus infection. Murine norovirus strains MNV-1 and CR3 was evaluated on Glycan-binding specificities and tissue tropism. Murine norovirus strains MNV-1 and CR3 evolved multiple strategies to bind different glycan receptors on murine macrophages, contributing to differences in tissue tropism in vivo.
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