June 1, 1993Journal of VirologyOpen Access

Modification of eukaryotic initiation factor 4F during infection by influenza virus

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Population

Cells infected by influenza virus

Design

Preclinical

Authors

Discussion

Suggests potential antiviral targets; leaves open relevance to human influenza therapy.

Population

Cells infected by influenza virus

Intervention

Influenza virus infection

Outcome

Dephosphorylation and inactivation of eIF-4E and translation ability of influenza virus mRNAs

Influenza virus regulates protein synthesis by decreasing the requirement for active eIF-4F and eIF-2, facilitating viral mRNA translation.

FEIGENBLUM et al. (1993) studied this question.

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