Translational control by influenza virus. Selective translation is mediated by sequences within the viral mRNA 5'-untranslated region.

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Population

Cells infected by influenza virus type A

Comparison

Chimeras containing the 5'-untranslated regions… vs Cellular mRNAs or chimeras with cellular 5'-UTR

Design

Preclinical

Authors

Discussion

Provides a molecular handle for selective viral translation inhibition; extends virology knowledge while leaving open clinical relevance.

Population

Cells infected by influenza virus type A

Intervention

Chimeras containing the 5'-untranslated regions (UTR) of influenza viral mRNAs

Comparator

Cellular mRNAs or chimeras with cellular 5'-UTR (e.g., secreted embryonic alkaline phosphatase 5'-UTR)

Outcome

Selective translation and protein synthesissurrogate

The selective translation of influenza viral mRNAs in infected cells is mediated by specific sequences within their 5'-untranslated regions.

Garfinkel et al. (1993) studied this question.

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