Key result
An exercise challenge (swimming) in rodents with incomplete T3 and T10 spinal cord injury revealed a progressive inability to maintain blood pressure despite normal resting hemodynamics.
Why the study?
Does an exercise challenge reveal cardiovascular dysfunction in rodents following incomplete T3 and T10 spinal cord injury?
Does an exercise challenge reveal cardiovascular dysfunction in rodents following incomplete T3 and T10 spinal cord injury?
Incomplete spinal cord injury in rodents causes chronic hemodynamic instability that is only apparent during exercise, despite normal resting cardiovascular parameters.
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Suggests exercise-induced BP instability risk in incomplete SCI despite normal rest; leaves open human translation and mechanisms.
Harman et al. (2018) studied Incomplete T3 and T10 spinal cord injury (n=16). Exercise challenge (swimming) vs. Rest / preinjury levels was evaluated on Cardiovascular responses (heart rate, blood pressure, echocardiography). An exercise challenge (swimming) in rodents with incomplete T3 and T10 spinal cord injury revealed a progressive inability to maintain blood pressure despite normal resting hemodynamics.
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