Key result
Passive hindlimb cycling improved stroke volume (167 µl vs 91 µl in no-exercise SCI rodents), whereas swim training had no cardiobeneficial effect.
Why the study?
Does passive hindlimb cycling or active upper-limb exercise improve cardiac contractile function in rodents with severe high-thoracic spinal cord injury?
Population
Rodents with severe high-thoracic (T2 level) spinal cord injury
Comparison
Passive hindlimb cycling or active upper-limb… vs Control without injury, and SCI no exercise
Design
Preclinical
Follow-up
25 days
Authors
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Does not support clinical adoption in spinal cord injury; extends preclinical data on passive exercise while leaving human translation open.
Does passive hindlimb cycling or active upper-limb exercise improve cardiac contractile function in rodents with severe high-thoracic spinal cord injury?
Absolute Event Rate: 167% vs 91%
p-value: p=<0.05
In a rodent model of severe spinal cord injury, passive lower-limb exercise improved flow-derived cardiac indexes, but neither passive lower-limb nor active upper-limb exercise corrected cardiac contractile dysfunction.
DeVeau et al. (2017) studied Severe high-thoracic spinal cord injury. Passive hindlimb cycling (PHLC) and active upper-limb exercise (SWIM) vs. No exercise (NO-EX) and uninjured control (CON) was evaluated on Stroke volume (p=<0.05). Passive hindlimb cycling improved stroke volume (167 µl vs 91 µl in no-exercise SCI rodents), whereas swim training had no cardiobeneficial effect.
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