Population
Newborn (NB) and adult (AD) rabbit ventricular myocytes
Comparison
Confocal microscopy of fluo-3 [Ca2+]i… vs Adult (AD) rabbit ventricular myocytes
Design
Preclinical
Authors
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May inform neonatal myocyte Ca2+ dynamics; leaves open translation to human ventricular maturation or function.
The absence of T-tubules and spatial separation of sarcolemmal Ca2+ entry from SR Ca2+ release channels in newborn ventricular myocytes leads to distinct subcellular Ca2+ gradients during excitation-contraction coupling.
Haddock et al. (1999) studied this question.
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