Key result
Desflurane significantly reduced the time to achieve a Modified Aldrete Score of 9 compared to sevoflurane (10.8 vs 16.2 minutes, p<0.001), but did not improve time to home readiness.
Why the study?
Does desflurane improve early recovery time and readiness for home discharge compared to sevoflurane in female patients undergoing daycare laparoscopic gynaecological surgery?
RCT (n=100)
Single-blind
Computer generated randomisation sheet
No
Does desflurane improve early recovery time and readiness for home discharge compared to sevoflurane in female patients undergoing daycare laparoscopic gynaecological surgery?
Absolute Event Rate: 10.8% vs 16.2%
p-value: p=<0.001
Desflurane provides faster early recovery than sevoflurane in outpatient gynaecological surgery, but does not expedite readiness for home discharge.
Supports desflurane for faster early recovery in ambulatory gynecologic laparoscopy; extends RCT evidence without expediting home discharge.
Both sevoflurane and desflurane have shorter emergence times compared to isoflurane based anaesthesia. Because of its pharmacological properties, desflurane appears to yield a rapid early and intermediate recovery compared with sevoflurane. The aim of this study was to assess the maintenance and emergence characteristics after anaesthesia with sevoflurane or desflurane. One hundred female patients scheduled to undergo daycare laparoscopic gynaecological surgery were enrolled for this prospective study. Patients were randomised into two groups to receive either desflurane [group I (D); n = 50] or sevoflurane [group II (S); n = 50] for maintenance of anaesthesia. The demographic data and the duration of procedure were comparable in both the groups. The early recovery time was shorter after maintenance of anaesthesia with desflurane compared with sevoflurane. However, this faster early recovery failed to lead to early readiness for home discharge. The intraoperative haemodynamic characteristics were comparable with both sevoflurane and desflurane. Both sevoflurane and desflurane provide a similar time to home readiness despite a faster early recovery with desflurane. The intraoperative haemodynamics are similar with both the agents.
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Jindal et al. (2011) conducted an RCT in Daycare gynaecological laparoscopic surgery (n=100). Desflurane vs. Sevoflurane 1-2% with 60% N2O in O2 was evaluated on Time to achieve Modified Aldrete Score of 9 (minutes) (p=<0.001). Desflurane significantly reduced the time to achieve a Modified Aldrete Score of 9 compared to sevoflurane (10.8 vs 16.2 minutes, p<0.001), but did not improve time to home readiness.
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