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August 1, 1977Acta Anaesthesiologica Scandinavica

The Blocking Effect of Epidural Analgesia on the Adrenocortical and Hyperglycemic Responses to Surgery

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Why the study?

Does epidural analgesia prevent the adrenocortical and hyperglycemic responses to hysterectomy compared to general anesthesia?

Population

Patients undergoing hysterectomy

Comparison

Epidural analgesia extending from Th4-S5 without… vs General anesthesia alone

Design

Other

Authors

AEA. EngquistFrederiksberg HospitalMBMogens R. BrandtRigshospitaletAFAlvito FernandesUniversity of Copenhagen

Discussion

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Implication

Extensive epidural analgesia may blunt surgical stress responses in hysterectomy; hypothesis-generating and should not yet change practice.

Structured PICO

Does epidural analgesia prevent the adrenocortical and hyperglycemic responses to hysterectomy compared to general anesthesia?

P
Population
Patients undergoing hysterectomy
I
Intervention
Epidural analgesia extending from Th4-S5 without general anesthesia, or combined with general anesthesia at various levels (Th10-S5, Th8-S4-5, Th4-6-S5)
C
Comparator
General anesthesia alone
O
Outcome
Adrenocortical (cortisol) and hyperglycemic responses to surgerysurrogate

Epidural analgesia extending from Th4 to S5 effectively abolishes the adrenocortical and hyperglycemic stress responses to hysterectomy.

Cite This Study

Engquist et al. (1977) studied this question.

synapsesocial.com/papers/6a706b852163a0a01bc4a33dhttps://doi.org/10.1111/j.1399-6576.1977.tb01227.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of plasma cyclic AMP, glucose and cortisol response to surgery by epidural analgesia1977 · 47 citations
  2. 2Attenuation of adrenocortical response to upper abdominal surgery with epidural blockade1983 · 37 citations
  3. 3Effect of epidural analgesia on postoperative insulin resistance as evaluated by insulin clamp technique1988 · 150 citations
  4. 4Influences of splanchnic nerve blockade on endocrine-metabolic responses to upper abdominal surgery1983 · 38 citations
  5. 5Effect of Epidural Analgesia on Metabolic Response to Major Upper Abdominal Surgery1983 · 37 citations