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June 1, 1988British journal of surgery

Effect of epidural analgesia on postoperative insulin resistance as evaluated by insulin clamp technique

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Why the study?

Does epidural analgesia reduce postoperative insulin resistance in patients undergoing elective upper abdominal surgery?

Population

18 patients undergoing elective upper abdominal surgery of moderate severity

Comparison

Epidural analgesia during surgery and epidural… vs General anaesthesia during surgery and systemic…

Design

Other

Follow-up

postoperative day 1

Authors

IUI. UchidaKumamoto UniversityTAT AsohOita University HospitalCSC ShirasakaKyushu University

Discussion

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Implication

Epidural analgesia may attenuate postoperative insulin resistance; hypothesis-generating and requires RCT confirmation before practice implications.

Structured PICO

Does epidural analgesia reduce postoperative insulin resistance in patients undergoing elective upper abdominal surgery?

P
Population
18 patients undergoing elective upper abdominal surgery of moderate severity
I
Intervention
Epidural analgesia during surgery and epidural morphine postoperatively
C
Comparator
General anaesthesia during surgery and systemic administration of analgesia postoperatively
O
Outcome
Postoperative insulin resistance evaluated by euglycaemic insulin clamp technique (glucose disposal M) on postoperative day 1surrogate

Epidural analgesia reduces postoperative insulin resistance and attenuates catecholamine and cortisol responses compared to general anesthesia in patients undergoing elective abdominal surgery.

Cite This Study

Uchida et al. (1988) studied this question.

synapsesocial.com/papers/6a7faa61138fa0ec199fea67https://doi.org/10.1002/bjs.1800750618
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Attenuation of adrenocortical response to upper abdominal surgery with epidural blockade1983 · 37 citations
  2. 2Glucose utilization and insulin secretion during surgery in man1974 · 83 citations
  3. 3Effects of arterial versus venous sampling on analysis of glucose kinetics in man1976 · 707 citations