Why the study?
Does general anaesthetic in combination with an epidural block reduce plasma corticosteroid concentrations in patients undergoing major surgery compared to general anaesthetic alone?
Population
Patients undergoing major surgery
Comparison
General anaesthetic in combination with an… vs General anaesthetic alone
Design
Cohort
Follow-up
during and after surgery
Authors
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Epidural block may lessen perioperative steroid cover needs; leaves open confirmation before practice change.
Does general anaesthetic in combination with an epidural block reduce plasma corticosteroid concentrations in patients undergoing major surgery compared to general anaesthetic alone?
Epidural blockade significantly inhibits the adrenocortical response to major surgery without causing cardiovascular collapse, questioning the necessity of corticosteroid cover for patients on corticosteroid drugs.
Gordon et al. (1973) studied this question.
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