Why the study?
Does captopril improve cardiac mitochondrial function in an in-vivo rabbit model of atherosclerosis?
Population
55 male Chinchilla rabbits
Comparison
Aqueous solution of captopril orally… vs Physiological saline orally or atherogenic 2%…
Design
Preclinical, randomized to one of four groups
Follow-up
12 weeks
Authors
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Captopril does not improve mitochondrial respiration in hypercholesterolemic rabbits; leaves open ACE inhibition effects on cardiac oxidative capacity.
Does captopril improve cardiac mitochondrial function in an in-vivo rabbit model of atherosclerosis?
In a rabbit model of atherosclerosis, captopril did not significantly improve the impairment of cardiac mitochondrial oxidative capacity induced by a hypercholesterolemic diet.
Kojić et al. (2006) studied this question.
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