June 22, 2012European Heart Journal
Phenotypic and pathophysiological heterogeneity in heart failure with preserved ejection fraction
Key result
Heart failure with preserved ejection fraction is a heterogeneous syndrome where traditional non-invasive parameters of diastolic function perform poorly in discriminating patients from controls.
Design
Editorial
Authors
Discussion
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Implication
Traditional diastolic parameters warrant cautious interpretation in suspected HFpEF; leaves open need for validated novel biomarkers in heterogeneous populations.
Key Points
- Contextualize clinical and mechanistic evidence surrounding diastolic stiffness, remodeling, and clinical features in heart failure with preserved ejection fraction (HFpEF).
- Synthesized findings from community-based observational cohorts evaluating clinical discrimination between HFpEF and heart failure with reduced ejection fraction (HFrEF).
- Assessed invasive hemodynamic data and echocardiographic markers of diastolic wall strain and left ventricular passive stiffness.
- Patients with HFpEF face substantial morbidity, re-hospitalization rates, and mortality comparable to HFrEF, yet lack targeted disease-modifying therapies.
- Impairments in active relaxation and passive ventricular stiffness characterize the syndrome, though traditional non-invasive diastolic parameters exhibit limited discriminatory ability in comorbid populations.
PICO
P
Population
Heart failure with preserved ejection fraction (HFpEF)
Highlights the phenotypic and pathophysiological heterogeneity of HFpEF and the challenges in using traditional non-invasive parameters to assess diastolic function.
Cite This Study
Shah et al. (2012) conducted an editorial in Heart failure with preserved ejection fraction (HFpEF). Heart failure with preserved ejection fraction is a heterogeneous syndrome where traditional non-invasive parameters of diastolic function perform poorly in discriminating patients from controls.