Key result
Severe sepsis or septic shock was associated with highly elevated median BNP (572 vs 581 ng/L) and NT-proBNP (6526 vs 4300 ng/L) levels, comparable to those in acute heart failure.
Why the study?
Are BNP and N-terminal pro-BNP levels comparable between patients with severe sepsis/septic shock and those with acute heart failure?
Observational (n=75)
No
Are BNP and N-terminal pro-BNP levels comparable between patients with severe sepsis/septic shock and those with acute heart failure?
BNP and NT-proBNP levels are highly elevated in severe sepsis and septic shock, comparable to levels seen in acute heart failure, limiting their diagnostic specificity for heart failure in septic patients.
No takes yet. Share an insight, caveat, or question.
Limits natriuretic peptide specificity for heart failure in sepsis; leaves open sepsis-adjusted thresholds in mixed ICU populations.
Rudiger et al. (2006) conducted an observational in Severe sepsis, septic shock, and acute heart failure (n=75). Severe sepsis or septic shock vs. Acute heart failure was evaluated on B-type natriuretic peptide (BNP) and N-terminal pro-BNP levels. Severe sepsis or septic shock was associated with highly elevated median BNP (572 vs 581 ng/L) and NT-proBNP (6526 vs 4300 ng/L) levels, comparable to those in acute heart failure.
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