Key result
Bio-impedance algorithm detects ~16% blood resistivity rise and tracks real-time brachial artery diameter waveforms.
Why the study?
Real-time artery diameter waveform assessment during the cardiac cycle can allow beat-to-beat pressure change measurement and long-term blood pressure monitoring, motivating the development of a self-calibrated bio-impedance-based sensor.
Can a self-calibrated bio-impedance sensor combined with an analytical mathematical model accounting for red blood cell orientation accurately estimate real-time brachial artery diameter waveforms and elasticity in healthy subjects?
Can a self-calibrated bio-impedance sensor combined with an analytical mathematical model accounting for red blood cell orientation accurately estimate real-time brachial artery diameter waveforms and elasticity in healthy subjects?
This proof-of-concept study demonstrates that accounting for red blood cell orientation effects and prior ultrasound calibration allows a wearable-ready bio-impedance sensor to track real-time arterial diameter waveforms and local elasticity for continuous cuffless blood pressure monitoring.
The real-time artery diameter waveform assessment during cardio cycle can allow the measurement of beat-to-beat pressure change and the long-term blood pressure monitoring. The aim of this study is to develop a self-calibrated bio-impedance-based sensor, which can provide regular measurement of the blood-pressure-dependence time variable parameters such as the artery diameter waveform and the elasticity. This paper proposes an algorithm based on analytical models which need prior geometrical and physiological patient parameters for more appropriate electrode system selection and hence location to provide accurate blood pressure measurement. As a result of this study, the red cell orientation effect contribution was estimated and removed from the bio-impedance signal obtained from the artery to keep monitoring the diameter waveform correspondence to the change of blood pressure.
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Mugeb et al. (2021) studied Healthy subjects undergoing arterial diameter waveform and blood pressure assessment (n=4). Self-calibrated four-electrode bio-impedance sensor with analytical modeling (Reo-32 system at 100 kHz, 3 mA) was evaluated on Real-time brachial artery diameter waveform and local arterial elastic modulus estimation after accounting for red blood cell orientation effects. The bio-impedance sensor algorithm identified a 16% blood resistivity increase from red cell orientation and restored real-time brachial artery diameter waveforms in 4 healthy subjects.
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