Key result
Higher serum triglycerides are linked to ~17% higher odds of stage 2 CKD.
Why the study?
The risk factors for early chronic kidney disease (CKD stage 2) in asymptomatic Chinese individuals undergoing routine health examination were undetermined.
Are routine clinical and lipid parameters, particularly serum triglyceride levels, associated with CKD stage 2 (eGFR 60-89 ml/min/1.73 m²) in asymptomatic young and middle-aged Chinese adults?
Cross-Sectional (n=9,100)
No
Are routine clinical and lipid parameters, particularly serum triglyceride levels, associated with CKD stage 2 (eGFR 60-89 ml/min/1.73 m²) in asymptomatic young and middle-aged Chinese adults?
Routine health examination parameters, particularly elevated triglycerides, low HDL-C, and carotid atherosclerosis, are independently associated with early kidney function decline (CKD stage 2) in young and middle-aged asymptomatic Chinese adults.
May support triglyceride assessment for early CKD risk in asymptomatic adults; leaves open causality and need for prospective validation.
BACKGROUND The aim of this study was to determine the risk factors for early chronic kidney disease (CKD) (GFR 60-89 ml/min/1.73 m²; CKD stage 2) in asymptomatic Chinese individuals undergoing routine health examination. MATERIAL AND METHODS This cross-sectional study enrolled 9100 individuals who received voluntary medical examinations between 10/01/2011 and 09/30/2017. Demographic data, clinical history, clinical examination, medication, smoking, alcohol, blood biochemistry, urinalysis, and carotid ultrasound were extracted from the medical records. All laboratory analyses were performed routinely. Multivariable logistic regression for factors predicting CKD stage 2 was performed. RESULTS A total of 9100 individuals were enrolled (age of 18-65 and 65.4% male). CKD stage 2 was found in 1989/9100 individuals (21.9%). Male gender (OR=6.711, 95%CI: 5.376-8.403, P<0.001), older age (OR=1.077, 95%CI: 1.068-1.086, P<0.001), hemoglobin levels (OR=1.051, 95%CI: 1.046-1.057, P<0.001), triglycerides levels (OR=1.174, 95%CI: 1.067-1.292, P=0.001), HDL-C (OR=0.539, 95%CI: 0.380-0.763, P<0.001), Lp(a) levels (OR=1.000, 95%CI: 1.000-1.001, P=0.03), and carotid atherosclerosis (OR=1.248, 95%CI: 1.005-1.550, P=0.045) were associated with CKD stage 2 among all subjects. Serum triglycerides levels were associated with CKD stage 2 in the 18-45 and 45-65 years of age subgroups. CONCLUSIONS Factors that are routinely assessed during routine health examinations (male gender, age, hemoglobin levels, triglycerides levels, HDL-C, Lp(a) levels, and carotid atherosclerosis) can help identify individuals at higher risk of having CKD stage 2. The Chinese dyslipidemia is characterized by high triglycerides and low HDL-C and occurs in young and middle-aged individuals. Those factors could help identify individuals at higher risk for CKD stage 2 and who could benefit from preventive treatments.
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Xue et al. (2019) conducted a cross-sectional in Chronic Kidney Disease (CKD) Stage 2 (GFR 60-89 ml/min/1.73 m²) (n=9,100). Serum triglycerides levels vs. Normal renal function (eGFR >90 ml/min/1.73 m²) was evaluated on CKD stage 2 (eGFR 60-89 ml/min/1.73 m²) (OR 1.174, 95% CI 1.067-1.292, p=0.001). Serum triglyceride levels were independently associated with a higher odds of CKD stage 2 (OR 1.174, 95% CI 1.067-1.292, P=0.001) in asymptomatic Chinese adults.
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