Key result
Higher lateral early-diastolic tissue velocity (Lat-e') predicted a lower risk of cardiovascular death and heart failure hospitalization (HR 0.79; 95% CI 0.63-0.99; P=0.044).
Why the study?
The potential of tissue velocity imaging for the prognosis of nonischemic left ventricular dysfunction had not been fully explored.
Does early-diastolic tissue velocity imaging of the lateral mitral annulus predict left ventricular functional recovery and clinical outcomes in patients with nonischemic left ventricular dysfunction?
Cohort (n=138)
Does early-diastolic tissue velocity imaging of the lateral mitral annulus predict left ventricular functional recovery and clinical outcomes in patients with nonischemic left ventricular dysfunction?
Answers are grounded in this paper and cite their sources.
Early-diastolic tissue velocity imaging of the lateral mitral annulus (Lat-e') is a significant predictor of LV functional recovery and clinical outcomes in patients with nonischemic LV dysfunction.
PURPOSE: We explored the potential of tissue velocity imaging (TVI) for prognosis of nonischemic left ventricular (LV) dysfunction (LVD). METHODS: We reviewed 138 nonischemic LVD patients (58 ± 14 years) who underwent both cardiac magnetic resonance (CMR) and echocardiography. Septal and lateral mitral annular TVI data were compared with late gadolinium enhancement (LGE) on CMR. During a mean follow-up of 24 months, recovery (>15%) of LV ejection fraction and clinical outcomes (cardiovascular death and heart failure hospitalization) were assessed. RESULTS: LGE was commonly observed in the basal anteroseptal, inferoseptal, and inferior segments, but infrequently observed in the anterolateral segment. LGE was associated with lower early diastolic, septal (Sep-e' = 5.2 ± 2.0 vs 6.9 ± 2.0 cm/s, P = .031) and lateral (Lat-e' = 7.3 ± 3.0 vs 9.5 ± 2.0 cm/s, P < .001) TVI. The relationship between Lat-e' and anterolateral LGE (area under the curve, AUC 0.834) was much better than that between Sep-e' and inferoseptal LGE (AUC 0.699). The 60 patients with LVD reversibility revealed higher Lat-e' (9.8 ± 2.0 vs 6.7 ± 2.2 cm/s, P < .001) and lower LGE burden (7.3 ± 9.0 vs 22 ± 10%, P < .001), while Lat-e' ≤ 7.8 cm/s appeared unfavorable for 31 events patients. On multivariate analyses, Lat-e' (HR 0.79, 95% CI 0.63-0.99, P = .044) and LVD reversibility (HR 0.53, 95% CI 0.16-0.90, P = .018) were still meaningful together with LGE segments and burden. CONCLUSION: Lat-e' was related with LVD reversibility and a significant predictor of clinical outcomes.
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Kim et al. (2019) conducted a cohort in Nonischemic left ventricular dysfunction (n=138). Lateral early-diastolic tissue velocity (Lat-e') was evaluated on Cardiovascular death and heart failure hospitalization (HR 0.79, 95% CI 0.63-0.99, p=0.044). Higher lateral early-diastolic tissue velocity (Lat-e') predicted a lower risk of cardiovascular death and heart failure hospitalization (HR 0.79; 95% CI 0.63-0.99; P=0.044).
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