Key result
Pharmacological blockade of the renin-angiotensin-aldosterone system improves insulin sensitivity and endothelial function, reducing the incidence of new-onset diabetes in high-risk patients.
Design
Review
Authors
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May support RAAS blockade for cardiometabolic risk reduction; leaves open need for dedicated prospective trials before practice change.
This review highlights the pathophysiological mechanisms linking RAAS activation to insulin resistance and cardiovascular disease, supporting the metabolic benefits of RAAS blockade.
Zhou et al. (2012) conducted a review in Metabolic syndrome, insulin resistance, and cardiovascular disease. Pharmacological blockade of RAAS was evaluated. Pharmacological blockade of the renin-angiotensin-aldosterone system improves insulin sensitivity and endothelial function, reducing the incidence of new-onset diabetes in high-risk patients.
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