January 1, 1995The Journal of Clinical Pharmacology

Treatment of Mild Hypertension with Low Once‐Daily Doses of a Sustained‐Release Capsule Formulation of Verapamil

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Why the study?

Does low-dose once-daily sustained-release verapamil reduce blood pressure in patients with mild hypertension?

Structured PICO

Does low-dose once-daily sustained-release verapamil reduce blood pressure in patients with mild hypertension?

Population

42 patients with mild hypertension (diastolic clinic blood pressures of 91 to 100 mm Hg inclusive)

Intervention

Verapamil sustained-release 120 mg capsules once daily for 4 weeks

Comparator

Baseline (after a 4-week placebo washout period)

Outcome

Clinic blood pressure and 24-hour ambulatory blood pressuresurrogate

Low-dose (120 mg) once-daily sustained-release verapamil effectively and safely reduces blood pressure and improves quality of life in patients with mild hypertension.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support low-dose verapamil for mild hypertension; leaves open confirmation in larger outcome trials.

Cite This Study

Davis et al. (1995) studied this question.

synapsesocial.com/papers/6a70732da7fbea1e440812f9 https://doi.org/10.1002/j.1552-4604.1995.tb04745.x

Topics

Hypertension management

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Treatment of Mild Hypertension with Low Once‐Daily Doses of a Sustained‐Release Capsule Formulation of Verapamil

Structured PICO

Discussion

Implication

Cite This Study

Topics

Treatment of Mild Hypertension with Low Once‐Daily Doses of a Sustained‐Release Capsule Formulation of Verapamil

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider