Why the study?
Does twice-daily oral verapamil reduce sitting diastolic blood pressure in adult patients with mild to moderate essential hypertension?
Population
21 adult patients with mild to moderate essential hypertension
Comparison
Verapamil hydrochloride oral twice daily for… vs Four weeks of placebo therapy (used as baseline)
Design
Cohort
Follow-up
4 weeks of active treatment
Authors
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May support verapamil for BP lowering in mild hypertension; hypothesis-generating and requires randomized confirmation before practice change.
Does twice-daily oral verapamil reduce sitting diastolic blood pressure in adult patients with mild to moderate essential hypertension?
Twice-daily oral verapamil safely and effectively reduces diastolic blood pressure in patients with mild to moderate essential hypertension, with efficacy correlating with trough plasma levels >80 ng/mL.
William H. Frishman (1986) studied this question.
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