Key result
MAS receptors mediate the effects elicited by AT1 antagonists, highlighting the pharmacological significance of the interplay between angiotensin AT1 and MAS receptors.
This perspective highlights the pharmacological importance of the interplay between AT1 and MAS receptors, suggesting MAS receptors mediate effects of AT1 antagonists.
No immediate change to AT1 antagonist therapy indicated; leaves open MAS receptor modulation as a hypothesis-generating target.
The interplay between angiotensin AT1 receptors and MAS receptors relies on several inward regulatory mechanisms from renin-angiotensin system (RAS) including the functional crosstalk between angiotensin II and angiotensin-(1-7), the competitive AT1 antagonism exhibited by angiotensin-(1-7), the antagonist feature assigned to AT1/MAS heterodimerization on AT1 signaling and the AT1-mediated downregulation of angiotensin-converting enzyme 2 (ACE2). Recently, such interplay has acquired an important significance to RAS Pharmacology since a few studies have supporting strong evidences that MAS receptors mediate the effects elicited by AT1 antagonists. The present Perspective provides an overview of the regulatory mechanisms involving AT1 and MAS receptors, their significance to RAS Pharmacology and the future directions on the interplay between angiotensin receptors.
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Pernomian et al. (2015) reported a review. Angiotensin AT1 receptor antagonists was evaluated. MAS receptors mediate the effects elicited by AT1 antagonists, highlighting the pharmacological significance of the interplay between angiotensin AT1 and MAS receptors.
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