Key result
Anti-TNF-alpha therapy has shown discouraging results in recent clinical trials for heart failure, prompting a critical analysis of its failure and potential new approaches.
Why the study?
Does anti-TNF-alpha therapy improve outcomes in patients with heart failure?
Population
Patients with heart failure
Design
Review
Authors
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Anti-TNF-alpha therapy lacks support in heart failure; leaves open alternative anti-inflammatory targets for prospective trials.
Does anti-TNF-alpha therapy improve outcomes in patients with heart failure?
Despite experimental evidence suggesting a role for TNF-alpha in heart failure progression, clinical trials of anti-TNF-alpha therapy have been unsuccessful, prompting a reevaluation of this therapeutic approach.
Balakumar et al. (2006) conducted a review in Heart failure. Anti-TNF-alpha therapy was evaluated. Anti-TNF-alpha therapy has shown discouraging results in recent clinical trials for heart failure, prompting a critical analysis of its failure and potential new approaches.
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