Key result
QTc prolongation was positively correlated with the degree of cardiac autonomic neuropathy in diabetic patients, demonstrating a sensitivity of 46% and specificity of 100%.
Why the study?
Is QTc prolongation associated with the severity of cardiac autonomic neuropathy in diabetic patients?
Observational (n=60)
Is QTc prolongation associated with the severity of cardiac autonomic neuropathy in diabetic patients?
QTc prolongation on ECG is highly specific for advanced grades of cardiac autonomic neuropathy in diabetic patients.
May aid detection of severe cardiac autonomic neuropathy in diabetes; leaves open whether ECG monitoring improves outcomes.
This study aims to detect the prevalence of QTc prolongation in diabetic patients and also to establish if any relationship with cardiac autonomic neuropathy. It was conducted on 60 diabetic patients. Cardiac autonomic neuropathy (CAN) was assessed by various non-invasive tests. Scoring and grading were done for CAN. Even QT interval and QTc interval were determined. 31 patients (52%) having grade I cardiac autonomic neuropathy had no prolonged QTc interval. While, 29 patients (48%) had QTc prolonged were associated with grade II, III and IV cardiac autonomic neuropathy. The sensitivity and specificity of prolonged QTc were 46% and 100%, respectively. QTc prolongation correlated positivity with degree of CAN in diabetic patients.
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Chavale et al. (2015) conducted an observational in Diabetes Mellitus (n=60). QTc prolongation vs. No QTc prolongation was evaluated on Cardiac autonomic neuropathy (CAN) grade (Sensitivity 46%, Specificity 100%). QTc prolongation was positively correlated with the degree of cardiac autonomic neuropathy in diabetic patients, demonstrating a sensitivity of 46% and specificity of 100%.
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