July 28, 2020Open Access

The Relationship between QT Interval Indices with Cardiac Autonomic Neuropathy in Diabetic Patients

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Type 2 diabetes mellitus (n=130). Intervention: Cardiac autonomic neuropathy vs. Diabetic patients without cardiac autonomic neuropathy. Primary outcome: QT dispersion (QTd) in milliseconds (p=0.02).

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Key result

Cardiac autonomic neuropathy in type 2 diabetic patients was associated with significantly higher QT dispersion (69 vs 58 msec, p=0.02) compared to patients without the condition.

Why the study?

Long QT interval and abnormal QT dispersion are associated with sudden death, prompting investigation into their relationship with cardiac autonomic neuropathy in diabetic patients.

Does the presence of cardiac autonomic neuropathy increase QT interval indices and QT dispersion in patients with type 2 diabetes?

Population

130 diabetic subjects

Comparison

Diabetic patients with CAN vs without CAN

Design

Cross-sectional study

Authors

MVmaryam vasheghaniResearch Institute for Endocrine Sciences FSFarzaneh SarvghadiResearch Institute for Endocrine Sciences MBMohammad Reza BeyranvandShahid Beheshti University of Medical Sciences

Discussion

Member takes

Implication

May support QTc screening for CAN in diabetes; leaves open whether it alters management or outcomes.

Study Design

Type

Cross-Sectional (n=130)

Multicenter

Structured PICO

Does the presence of cardiac autonomic neuropathy increase QT interval indices and QT dispersion in patients with type 2 diabetes?

Population

130 type 2 diabetic patients aged 18 to 75 years with sinus rhythm were evaluated to determine the relationship between cardiac autonomic neuropathy and QT interval indices.

Exposure

Presence of Cardiac Autonomic Neuropathy (CAN)

Comparator

Absence of Cardiac Autonomic Neuropathy (CAN)

Outcome

QT interval indices including QT minimum (QT min), QT maximum (QT max), QT mean, QT corrected (QTc), and QT dispersion (QTd) assessed from standard 12-lead ECGsurrogate

Main Result

Mean Difference: 11

Absolute Event Rate: 69% vs 58%

p-value: p=0.02

In patients with type 2 diabetes, the presence of cardiac autonomic neuropathy is associated with increased QT dispersion and maximum QT intervals, which may indicate a higher risk for ventricular arrhythmias.

Limitations

The study was performed in a single center with a small number of patients, lowering external validity.
The QT interval was measured and calculated manually, introducing the possibility of operator error.
Other factors which affect QT interval such as electrolyte imbalance (hypo or hyper-kalemia, hypo or hyper-calcemia) were not evaluated.
Single center with a small number of patients
QT interval was measured and calculated manually, introducing the possibility of operator error
Other factors which affect QT interval such as electrolyte imbalance (hypo or hyper-kalemia, hypo or hyper-calcemia) were not evaluated

Cite This Study

vasheghani et al. (2020) conducted a cross-sectional in Type 2 diabetes mellitus (n=130). Cardiac autonomic neuropathy vs. Diabetic patients without cardiac autonomic neuropathy was evaluated on QT dispersion (QTd) in milliseconds (p=0.02). Cardiac autonomic neuropathy in type 2 diabetic patients was associated with significantly higher QT dispersion (69 vs 58 msec, p=0.02) compared to patients without the condition.

synapsesocial.com/papers/6a7a4c59e357fbdac5897371 https://doi.org/10.21203/rs.3.rs-47922/v1

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The Relationship between QT Interval Indices with Cardiac Autonomic Neuropathy in Diabetic Patients

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

The Relationship between QT Interval Indices with Cardiac Autonomic Neuropathy in Diabetic Patients

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider