Key result
Cardiac autonomic neuropathy in T2D is linked to prolonged QTc intervals up to ~481 ms.
Why the study?
Cardiovascular autonomic neuropathy is a severely debilitating yet underdiagnosed complication of diabetes.
Do QTc prolongation and QT dispersion on ECG correlate with the presence and severity of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus?
Population
80 cases of diabetes mellitus
Comparison
Presence vs absence of cardiac autonomic neuropathy
Authors
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QTc on ECG may support screening for autonomic neuropathy in type 2 diabetes; leaves open need for prospective validation before practice change.
Cross-Sectional (n=80)
No
Do QTc prolongation and QT dispersion on ECG correlate with the presence and severity of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus?
p-value: p=0.001
QTc prolongation and QT dispersion on a standard ECG can serve as simple, easily evaluated markers for diagnosing and grading the severity of cardiac autonomic neuropathy in patients with type 2 diabetes.
Mahajan et al. (2019) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=80). Cardiac autonomic neuropathy vs. No cardiac autonomic neuropathy was evaluated on QTc interval (p=0.001). Cardiac autonomic neuropathy in patients with type 2 diabetes was significantly associated with prolonged QTc intervals (ranging from 0.432 to 0.481 seconds based on severity) compared to patients without the condition (0.344 seconds).
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