Why the study?
Cardiac autonomic neuropathy causes silent myocardial infarction and sudden death in diabetics, so recognizing early asymptomatic cardiac dysautonomia could help delay or arrest progression.
Does QTc prolongation correlate with cardiovascular autonomic neuropathy in patients with Type 2 Diabetes Mellitus?
Population
Patients with Type 2 diabetes
Comparison
Group A vs group B vs group C by duration of diabetes
Design
Cross-sectional study
Key result
The prevalence of definite cardiovascular autonomic neuropathy significantly increased with the duration of Type 2 diabetes, rising from 8% at <5 years to 58% at >10 years (p<0.001).
Authors
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Longer T2DM duration was associated with higher CAN prevalence; extends prior observations but leaves open prospective validation of QTc screening.
Cross-Sectional (n=120)
No
Does QTc prolongation correlate with cardiovascular autonomic neuropathy in patients with Type 2 Diabetes Mellitus?
Absolute Event Rate: 58% vs 8%
p-value: p=<0.001
QTc interval prolongation on ECG correlates significantly with cardiovascular autonomic dysfunction in Type 2 diabetes and may serve as a diagnostic tool for cardiac autonomic neuropathy.
Inapakolla et al. (2019) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=120). Duration of Type 2 Diabetes vs. <5 years duration was evaluated on Prevalence of definite cardiovascular autonomic neuropathy (CAN) (p=<0.001). The prevalence of definite cardiovascular autonomic neuropathy significantly increased with the duration of Type 2 diabetes, rising from 8% at <5 years to 58% at >10 years (p<0.001).
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