Key result
In a finite element model, material changes altering mitral valve anisotropy profoundly altered valvular function, with abnormally stiffened valves closing more slowly and producing lower peak frequencies.
Population
Dynamic nonlinear fluid-coupled finite element model of the mitral valve leaflets and chordae tendinae
Comparison
Perturbation of material parameters… vs Material changes that preserved anisotropy vs…
Design
Preclinical
Authors
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Stiffened mitral valves may yield unexpectedly lower closure frequencies; challenges stiffness-frequency axiom and leaves open in vivo validation.
Computational modeling demonstrates that the relationship between mitral valve stiffness and closure sound frequency is complex, challenging the axiom that increased stiffness always leads to higher frequencies.
Einstein et al. (2005) studied Mitral valve disease. Perturbing material parameters (stiffness, volume fraction, and splay of collagen fibers) vs. Normal material parameters was evaluated on Acoustic signatures of valve closure sounds (peak frequencies). In a finite element model, material changes altering mitral valve anisotropy profoundly altered valvular function, with abnormally stiffened valves closing more slowly and producing lower peak frequencies.
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