What question did this study set out to answer?

To compare the efficacy and safety of continuous intravenous nitroglycerine infusion against sublingual nifedipine for managing blood pressure in patients with severe pre-eclampsia.

December 7, 2007Clinical and Experimental Pharmacology and Physiology

Efficacy of Nitroglycerine Infusion Versus Sublingual Nifedipine in Severe Pre‐eclampsia: A Randomized, Triple‐blind, Controlled Trial

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Authors

SMS Manzur‐Verástegui PMPB Mandeville AGAntonio Gordillo‐MoscosoAutonomous University of San Luis Potosí

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Implication

Randomized triple-blind trial shows faster, more precise blood pressure control with intravenous nitroglycerine versus sublingual nifedipine in severe pre-eclampsia, indicating a safe alternative.

Key Points

To compare the efficacy and safety of continuous intravenous nitroglycerine infusion against sublingual nifedipine for managing blood pressure in patients with severe pre-eclampsia.
Randomized, triple-blind, controlled trial in 32 women with severe pre-eclampsia undergoing controlled plasma volume expansion and magnesium sulfate therapy.
Patients received either continuous intravenous nitroglycerine infusion or sublingual nifedipine.
Evaluated maternal blood pressure, maternal and fetal heart rates, and perinatal adverse events using mixed models and classical parametric and non-parametric tests.
Both treatments triggered significant hypotensive responses, but the reduction with intravenous nitroglycerine was faster, greater, and exhibited less variability.
Maternal heart rate increased less with nitroglycerine than with nifedipine (4.6 ± 4.4 vs 8.6 ± 5.3 bpm), with no significant changes in fetal heart rate in either group.
Perinatal fetal-maternal adverse events occurred in 40% of patients in both groups, primarily including headache, flushing, palpitations, and nausea.

Cite This Study

Manzur‐Verástegui et al. (2007) studied this question.

synapsesocial.com/papers/6a707afa5d37378ac1dd95f3 https://doi.org/10.1111/j.1440-1681.2007.04838.x

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Implication

Randomized triple-blind trial shows faster, more precise blood pressure control with intravenous nitroglycerine versus sublingual nifedipine in severe pre-eclampsia, indicating a safe alternative.

Efficacy of Nitroglycerine Infusion Versus Sublingual Nifedipine in Severe Pre‐eclampsia: A Randomized, Triple‐blind, Controlled Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Efficacy of Nitroglycerine Infusion Versus Sublingual Nifedipine in Severe Pre‐eclampsia: A Randomized, Triple‐blind, Controlled Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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