What is the clinical evidence from this study?

Study design: RCT. Population: Severe hypertension in pregnancy (n=200). Intervention: Sublingual nifedipine vs. Intravenous hydrallazine 5 mg. Primary outcome: Decreasing blood pressure.

What question did this study set out to answer?

To compare the efficacy of sublingual nifedipine versus intravenous hydralazine in managing acute severe hypertension in pregnancy and assess its feasibility for rural healthcare settings.

February 1, 1996Journal of obstetrics and gynaecology research

Sublingual Nifedipine Compared with Intravenous Hydrallazine in the Acute Treatment of Severe Hypertension in Pregnancy: Potential for Use in Rural Practice

Q: What does this research mean for the field?

Sublingual nifedipine (5 mg) is comparable in efficacy to intravenous hydrallazine (5 mg) for decreasing blood pressure in the acute treatment of severe hypertension in pregnancy, and can be easily administered by nurses. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Sublingual nifedipine (5 mg) was comparable to intravenous hydrallazine (5 mg) in decreasing blood pressure for the acute treatment of severe hypertension in pregnancy.

Why the study?

Does sublingual nifedipine reduce blood pressure as effectively as intravenous hydrallazine in pregnant women with severe hypertension?

Key Points

To compare the efficacy of sublingual nifedipine versus intravenous hydralazine in managing acute severe hypertension in pregnancy and assess its feasibility for rural healthcare settings.
Randomized trial conducted in 200 consecutive pregnant patients (>28 weeks gestation, diastolic blood pressure >120 mmHg) admitted to Kuala Terengganu General Hospital, Malaysia.
Group I received sublingual nifedipine 5 mg (repeated at 15 minutes if diastolic blood pressure remained >120 mmHg); Group II received intravenous hydralazine 5 mg under the same schedule.
Hydralazine infusion was initiated in both arms if diastolic blood pressure remained above 120 mmHg after 30 minutes; comparisons were analyzed using the Chi-square test (p < 0.05).
No statistically significant difference emerged between sublingual nifedipine and intravenous hydralazine in blood pressure reduction efficacy (p >= 0.05).
Maternal and neonatal outcomes, including incidence of postpartum hemorrhage, fetal distress, and Cesarean section rates, did not differ significantly between arms.
Nursing staff administered sublingual nifedipine without procedural difficulty during observational evaluation.

Study Design

Type

RCT (n=200)

Randomization

Randomized

Multicenter

Structured PICO

Does sublingual nifedipine reduce blood pressure as effectively as intravenous hydrallazine in pregnant women with severe hypertension?

Population

200 pregnant women with severe hypertension (ongoing viable pregnancy > 28 weeks and diastolic blood pressure > 120 mmHg) admitted to a general hospital in Malaysia.

Intervention

Sublingual nifedipine 5 mg, repeated after 15 minutes if DBP > 120 mmHg.

Comparator

Intravenous hydrallazine 5 mg, repeated after 15 minutes if DBP > 120 mmHg.

Outcome

Efficacy of therapy for decreasing blood pressure.surrogate

Sublingual nifedipine is as effective as intravenous hydrallazine for acute severe hypertension in pregnancy and can be easily administered by nurses, making it suitable for rural practice.

Discussion

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Implication

Sublingual nifedipine enables nurse-led care for severe hypertension in pregnancy; extends randomized options for resource-limited settings.

Cite This Study

Jegasothy et al. (1996) conducted an RCT in Severe hypertension in pregnancy (n=200). Sublingual nifedipine vs. Intravenous hydrallazine 5 mg was evaluated on Decreasing blood pressure. Sublingual nifedipine (5 mg) was comparable to intravenous hydrallazine (5 mg) in decreasing blood pressure for the acute treatment of severe hypertension in pregnancy.

synapsesocial.com/papers/6a18c5e50b0ae5b64a91c235 https://doi.org/10.1111/j.1447-0756.1996.tb00930.x

Topics

Hypertension management

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Implication

Sublingual nifedipine enables nurse-led care for severe hypertension in pregnancy; extends randomized options for resource-limited settings.

Sublingual Nifedipine Compared with Intravenous Hydrallazine in the Acute Treatment of Severe Hypertension in Pregnancy: Potential for Use in Rural Practice

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Topics

Sublingual Nifedipine Compared with Intravenous Hydrallazine in the Acute Treatment of Severe Hypertension in Pregnancy: Potential for Use in Rural Practice

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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