Why the study?
Does morphine sulphate reduce ventricular vulnerability to fibrillation in anaesthetised dogs?
Does morphine sulphate reduce ventricular vulnerability to fibrillation in anaesthetised dogs?
Morphine sulphate appears to protect against ventricular fibrillation via central vagal activation in a canine model.
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Hypothesis-generating for vagal anti-fibrillatory effects in canines; leaves open translation to human VF management.
Administration of morphine sulphate to 16 anaesthetised dogs resulted in significant reduction in ventricular vulnerability to fibrillation. The repetitive extrasystole threshold was used as an index of vulnerability to ventricular fibrillation. In 14 dogs, atropine or vagotomy abolished this response. This suggests that central vagal activation by morphine sulphate may be protective against ventricular fibrillation.
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DeSilva et al. (1978) studied this question.
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