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March 1, 1977Journal of VirologyOpen Access

Quantitation of herpes simplex virus type 1 RNA in infected HeLa cells

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Population

HeLa cells infected with herpes simplex virus type 1 (HSV-1)

Design

Preclinical

Follow-up

6 hours

Authors

JSJames R. StringerRutgers, The State University of New JerseyLHL E HollandIIT Research InstituteRSRonald SwanstromUniversity of North Carolina at Chapel Hill

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Implication

Suggests potential early antiviral window in HSV; extends viral kinetics data but leaves open clinical translation.

Structured PICO

P
Population
HeLa cells infected with herpes simplex virus type 1 (HSV-1)
I
Intervention
Infection with HSV-1 (analyzed at 2h and 6h post-infection)
O
Outcome
Size and amount of HSV-specific RNA synthesizedsurrogate

The study details the kinetics and characteristics of HSV-1 RNA synthesis and polyadenylation in infected HeLa cells.

Cite This Study

Stringer et al. (1977) studied this question.

synapsesocial.com/papers/6a707e1735aa2c282ce1cfd6https://doi.org/10.1128/jvi.21.3.889-901.1977
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RNA synthesis in cells infected with herpes simplex virus. XII. Sequence complexity and properties of RNA differing in extent of adenylation1976 · 30 citations
  2. 2Ribonucleic Acid Synthesis in Cells Infected with Herpes Simplex Virus1969 · 109 citations
  3. 3Detection of Polyadenylic Acid Sequences in Viral and Eukaryotic RNA1972 · 218 citations
  4. 4The determination of the molecular weight of ribonucleic acid by polyacrylamide-gel electrophoresis. The effects of changes in conformation1969 · 771 citations
  5. 5Regulation of Herpesvirus Macromolecular Synthesis: Nuclear Retention of Nontranslated Viral RNA Sequences1974 · 84 citations