September 1, 1972Proceedings of the National Academy of Sciences
Ribonucleic Acid Synthesis in Cells Infected with Herpes Simplex Virus: Controls of Transcription and of RNA Abundance
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Population
Human epidermoid carcinoma cells infected with herpes simplex virus subtype 1 at a multiplicity of 8 plaque…
Design
Preclinical
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Overview
Suggests dual transcriptional controls in HSV-1; hypothesis-generating and leaves open validation in human cells or disease models.
Structured PICO
P
Population
Human epidermoid carcinoma (HEp-2) cells infected with herpes simplex virus subtype 1 (HSV-1) at a multiplicity of 8 plaque forming units per cell
I
Intervention
Analysis of viral RNA synthesis and transcription controls at 2 hours and 8 hours post-infection
O
Outcome
Kinetics of hybridization of labeled viral DNA and excess viral RNA to determine RNA abundance and transcription controls
The study demonstrates that herpes simplex virus transcription is regulated by both on-off and abundance controls, with most structural components synthesized as an early viral function.
Cite This Study
Frenkel et al. (1972) studied this question.
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